반응식
NC1C2CCCCC=2C=CC=1.N(C1C2CCCCC=2C=CC=1)C(C)=O.C(NC1C=CC=CC=1)(=O)C.[NH:36]([C:40]1[C:49]2[CH2:48][CH2:47][CH2:46][CH2:45][C:44]=2[C:43]([N+:50]([O-:52])=[O:51])=[CH:42][CH:41]=1)C(C)=O>>[NH2:36][C:40]1[C:49]2[CH2:48][CH2:47][CH2:46][CH2:45][C:44]=2[C:43]([N+:50]([O-:52])=[O:51])=[CH:42][CH:41]=1참가 물질
실험 절차
1-Amino-5,6,7,8-tetrahydronaphthaline was converted to 1-acetamino-5,6,7,8-tetrahydronaphthaline according to Method A2a, Step 1. The acetanilide was converted to 1-acetamino-4-nitro-5,6,7,8-tetrahydronaphthaline according according to Method A2a, Step 2. The acetanilide was deprotected according to Method A2a, Step 3 to give 1-amino-4-nitro-5,6,7,8-tetrahydronaphthaline. The aniline was converted to 4-nitro-5,6,7,8-tetrahydro-1-naphthyl isothiocyanate according to Method A2a, Step 3. 1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-nitro-5,6,7,8-tetrahydro-1-naphthyl isothiocyanate according to Method C1a to give 2-(4-nitro-5,6,7,8-tetrahydro-1-naphthylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford 1-isobutyl-2-(4-nitro-5,6,7,8-tetrahydro-1-naphthylimino)-3-thia-1-azaspiro[4.4]nonane.
출처 및 근거
- ORD 기록
- ord-5781f5856e034f57b5bae34a5a435a8f
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06353006B1
연결된 노트
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