반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[S:18])=[C:12]([CH3:19])[CH:11]=1)#[N:9].[OH:20]C[CH2:22][NH2:23].Cl.Cl[CH2:26][C:27]1([NH2:32])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[C:8]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([CH3:19])[CH:11]=1)#[N:9].[OH:20][CH2:7][C:2]1([NH2:1])[CH2:3][CH2:4][CH2:5][CH2:6]1.[C:22]([C:6]1[CH:5]=[CH:4][C:19]([C:12]2[CH:11]=[CH:10][CH:15]=[CH:14][C:13]=2[N:16]=[C:17]2[S:18][CH2:26][C:27]3([CH2:31][CH2:30][CH2:29][CH2:28]3)[NH:32]2)=[CH:2][CH:7]=1)#[N:23]참가 물질
7
반응물 4
생성물 3
실험 절차
4-Cyano-2-methylaniline was prepared according to Method A1a. The aniline was converted to 4-cyano-2-methylphenyl isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 4-cyano-2-methylphenyl isothiocyanate according to Method C1e to give 2-(4-cyanophenylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 2-(4-cyano-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
출처 및 근거
- ORD 기록
- ord-63226149c48c40b8b0a0a75bae0fb5b7
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06353006B1
연결된 노트
불러오는 중…