N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl)-4-bromomethyl-benzamide → N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-imidazol-1-ylmethyl-benzamide

HRID 276709노트

반응식

HRID 276709 반응식
[C:1]([C:3]([NH:6][C:7]([CH:9]([NH:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22]Br)=[CH:18][CH:17]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:8])([CH3:5])[CH3:4])#[N:2].[NH:25]1[CH:29]=[CH:28][N:27]=[CH:26]1.[Na]>C1COCC1>[C:1]([C:3]([NH:6][C:7]([CH:9]([NH:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:18][CH:17]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:8])([CH3:5])[CH3:4])#[N:2]

참가 물질

4

반응물 2

HCID 18316679N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl)-4-bromomethyl-benzamideHCID 57373095Imidazole sodium

생성물 1

HCID 18316714N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-imidazol-1-ylmethyl-benzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-bromomethyl-benzamide (0.18 mmol) is dissolved in THF (1 ml) and sodium-imidazol (0.41 mmol) is added and the reaction mixture stirred at RT over night. After evaporation of the solvent, the residue is extracted with ethyl acetate. The extract is washed with water, dried over magnesium sulfate and evaporated. An oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained.

후처리

  1. customAfter evaporation of the solvent
  2. extractionthe residue is extracted with ethyl acetate
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customAn oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained

출처 및 근거

ORD 기록
ord-e34d418ffe5448dda97e389fde424e4c
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353017B1

반응 노트

불러오는 중…