Water → Ethanol, 2-(ethylphenylamino)-, 1-acetate

HRID 276743

반응식

HRID 276743 반응식
[CH2:1]([N:3]([CH2:10][CH2:11][OH:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].C(N(CC)CC)C.[C:20](Cl)(=[O:22])[CH3:21].O>CC(C)=O>[C:20]([O:12][CH2:11][CH2:10][N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)(=[O:22])[CH3:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 623382-(N-ethylanilino)ethanol

생성물 1

HCID 113382Ethanol, 2-(ethylphenylamino)-, 1-acetate수율 99.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

51.8 g of 2-(N-ethylanilino)ethanol and 31.7 g of triethylamine were dissolved in 300 ml of acetone. To this was added slowly 25 g of acetyl chloride while cooling the resulting reaction solution with ice water. The resulting solution was then stirred for 6 hours at room temperature for reaction. 200 ml of water was then poured into the solution. The organic layer was extracted with ethyl acetate and dried with sodium sulfate. The solvent was then distilled off under reduced pressure to obtain 64.9 g of 2-(N-ethylanilino)ethyl acetate.

후처리

  1. temperaturewhile cooling
  2. extractionThe organic layer was extracted with ethyl acetate
  3. dry with materialdried with sodium sulfate
  4. distillationThe solvent was then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-bd2e94ce3b8043488d2dd31264c76a54
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355396B1

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