1-(4-Chlorophenyl)-2-methylpiperazine → 2-Methyl-1-phenylpiperazine

HRID 276891노트

반응식

HRID 276891 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])=[CH:4][CH:3]=1.[H][H]>CO.[C].[Pd]>[C:5]1([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

참가 물질

5

반응물 2

HCID 982891-(4-Chlorophenyl)-2-methylpiperazineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 980862-Methyl-1-phenylpiperazine수율 100%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

1-(4-chlorophenyl)-2-methylpiperazine (300 mg, 1.4 mmol) was dissolved in methanol (3 ml), and the resulting solution was mixed with palladium carbon (150 mg) and stirred at a room temperature for 21 hours in an atmosphere of hydrogen. The reaction solution was filtered, and the thus obtained residue was thoroughly washed with ethanol. The washed solution and filtrate were combined, and the solvent was evaporated therefrom under a reduced pressure to obtain 260 mg of the title compound (1.4 mmol, 100% in yield).

후처리

  1. filtrationThe reaction solution was filtered
  2. washthe thus obtained residue was thoroughly washed with ethanol
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-5f1c9b4ff6e7447ebc3163247c5f535a
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355642B1

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