Ammonia → 3-(Piperazin-1-yl)benzamide

HRID 276895

반응식

HRID 276895 반응식
[C:1]([C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1)#[N:2].N.S(=O)(=O)(O)[OH:17]>>[C:1]([C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1)(=[O:17])[NH2:2]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 114809021-(3-Cyanophenyl)piperazine

생성물 1

HCID 155426373-(Piperazin-1-yl)benzamide수율 58%

실험 절차

1-(3-Cyanophenyl)piperazine (1.6 g, 8.3 mmol) was dissolved in 90% sulfuric acid aqueous solution (17 ml) and stirred at a room temperature for 2 days. The reaction solution was slowly added drbpwise to a mixture consisting of ice (65 g) and 28% aqueous ammonia (65 ml), and the reaction product was extracted with chloroform. The resulting extract was washed with saturated brine and dried with sodium sulfate, and then the solvent was evaporated under a reduced pressure to obtain 990 mg of the title compound (4.9 mmol, 58% in yield).

후처리

  1. additionThe reaction solution was slowly added drbpwise to a mixture
  2. extractionthe reaction product was extracted with chloroform
  3. extractionThe resulting extract
  4. washwas washed with saturated brine
  5. dry with materialdried with sodium sulfate
  6. customthe solvent was evaporated under a reduced pressure

출처 및 근거

ORD 기록
ord-77e9194d52164950aa92ca496db25f7c
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355642B1

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