3-(2-Furyl)acrolein → 7-Bromo-2-(2-furan-2-yl-vinyl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

반응식

[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[O:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[CH:29]=[CH:30][CH:31]=O>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:31]([CH:30]=[CH:29][C:25]3[O:24][CH:28]=[CH:27][CH:26]=3)[N:9]=[C:4]2[CH:3]=1

참가 물질

반응물 3

HCID 121743-(2-Furyl)acrolein

HCID 114353934-Bromo-2,6-diaminopyridine

HCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

생성물 1

HCID 701696377-Bromo-2-(2-furan-2-yl-vinyl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

실험 절차

The title compound, MS m/e (%): 305 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 3-(2-furyl)-acrolein. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

출처 및 근거

ORD 기록: ord-528606ffbbb541e29b2bc01b80922d5b
출처 데이터셋: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06355653B1

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