3-Methyl-2-thiophenecarboxaldehyde → 7-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

반응식

[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[CH3:24][C:25]1[CH:29]=[CH:28][S:27][C:26]=1[CH:30]=O>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:30]([C:26]3[S:27][CH:28]=[CH:29][C:25]=3[CH3:24])[N:9]=[C:4]2[CH:3]=1

참가 물질

반응물 3

HCID 799113-Methyl-2-thiophenecarboxaldehyde

HCID 114353934-Bromo-2,6-diaminopyridine

HCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

생성물 1

HCID 183136927-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

실험 절차

The title compound, MS m/e (%): 309 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 3-methylthiophene-2-carboxaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

출처 및 근거

ORD 기록: ord-e22fa2c3d371489a8a509ce5670f088a
출처 데이터셋: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06355653B1

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