Dimethylformamide → HCID 10654815, 화합물

HRID 277174노트

반응식

HRID 277174 반응식
C([Li])CCC.[CH3:6][C:7]1[C:12]2[CH:13]=[CH:14][O:15][C:11]=2[C:10]([CH3:16])=[CH:9][CH:8]=1.CN(C)[CH:19]=[O:20].C(OCC)(=O)C>O1CCCC1>[CH3:6][C:7]1[C:12]2[CH:13]=[C:14]([CH:19]=[O:20])[O:15][C:11]=2[C:10]([CH3:16])=[CH:9][CH:8]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 331094,7-DimethylbenzofuranHCID 178418339Butyllithium

생성물 1

HCID 10654815HCID 10654815, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

18.4 ml n-butyl lithium (1.56 M solution in hexane) was added to 50 ml solution of 3.5 g 4,7-dimethylbenzofuran in anhydrous tetrahydrofuran at −35° C. in a nitrogen atmosphere. After stirring for 15 minutes,5.6 ml N,N-dimethylformamide was added dropwise thereto, and the temperature was raised to room temperature. Ethyl acetate was added to the reaction mixture, and the organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resulting crude crystals were washed with n-hexane to give 2.3 g of 4,7-dimethylbenzofuran-2-carbaldehyde as apale yellow solid.

후처리

  1. washthe organic layer was washed with brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated
  4. washthe resulting crude crystals were washed with n-hexane

출처 및 근거

ORD 기록
ord-c4d8e4f73b004d48b88619140d9445fc
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355669B1

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