Potassium Hydroxide → N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

HRID 27718

반응식

HRID 27718 반응식
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([NH:12][C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:14])=[C:7]([O:28][CH3:29])[CH:6]=1)(=O)C.[OH-].[K+]>C(O)C>[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([NH:12][C:13]([N:15]2[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:19][CH2:20]2)=[O:14])=[C:7]([O:28][CH3:29])[CH:6]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 20538750N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

생성물 1

HCID 20538744N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide (e9) (1.4 g) in ethanol (20 ml) was refluxed for 1 hour with an aqueous (4 ml) solution of potassium hydroxide (0.6 g). The solvent was removed by evaporation and the residue extracted with ethyl acetate. Chromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent yielded N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide (e10).

후처리

  1. customThe solvent was removed by evaporation
  2. extractionthe residue extracted with ethyl acetate
  3. customChromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent

출처 및 근거

ORD 기록
ord-adab6185963e48b29418236becec0751
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04223034

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