Ethyl bromoacetate → Ethyl N-(3-benzoylphenyl)-glycinate

HRID 27722노트

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[C:5]([C:4]1[CH:3]=[C:2]([NH:1][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:15]=[CH:14][CH:13]=1)(=[O:6])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

반응물 2

HCID 7748Ethyl bromoacetate

HCID 17817Methanone, (3-aminophenyl)phenyl-

생성물 1

HCID 23341870Ethyl N-(3-benzoylphenyl)-glycinate수율 66%

실험 절차

4.5 g Ethyl N-(3-benzoylphenyl)-glycinate, obtained at a 66% yield from 3-aminobenzophenone and ethyl bromoacetate by an analogous procedure to that of Example 1, are heated in the presence of 10 ml dimethyl sulphate and 2 ml water to 100° C. for 11/2 hours.

출처 및 근거

ORD 기록: ord-7f04aaabcb704bf68611636b6f828286
출처 데이터셋: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04223039

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