Water → HCID 54408223, 화합물

HRID 277294

반응식

HRID 277294 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7])#[N:2].[CH3:11][C:12]([C:14]1[CH:19]=[C:18]([C:20]#[N:21])[CH:17]=[CH:16][CH:15]=1)=O.OS(O)(=O)=O.O>C(O)(=O)C>[C:20]([C:18]1[CH:19]=[C:14]([CH:12]=[CH:11][C:6]([C:5]2[CH:8]=[CH:9][CH:10]=[C:3]([C:1]#[N:2])[CH:4]=2)=[O:7])[CH:15]=[CH:16][CH:17]=1)#[N:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 802223-AcetylbenzonitrileHCID 90670m-Formylbenzonitrile

생성물 1

HCID 54408223HCID 54408223, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Cyanobenzaldehyde (3.0 g, 23.0 mmol) and 3-cyanoacetophenone (3.34 g, 23.0 mmol) in glacial acetic acid (5 mL) and concentrated H2SO4 (3.66 mL, 69 mmol) was stirred at room temperature for 72 hours. Water (200 mL) was added and the reaction filtered. The precipitate was washed with water (2×200 mL) and dried in vacuo to give 3,3′-dicyanochalcone as an off-white solid. MS (APCI) m/z 258 (M+−1, 100%). 13C NMR (50 MHz, d6-DMSO): δ111.7, 117.8, 118.0, 123.0, 129.7, 131.6, 132.1, 132.4, 133.3, 133.5, 135.3, 136.1, 137.4, 142.1, 187.3.

후처리

  1. filtrationthe reaction filtered
  2. washThe precipitate was washed with water (2×200 mL)
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-14ffe8cfbb58484792efb5d5d57e1733
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355683B1

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