Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Benzaldehyde, 4-(phenylmethoxy)- | HCID 78109 | — |
| 반응물 | 4-methyl-3-oxo-N-phenylpentanamide | HCID 10219899 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide | HCID 54048391 | — |
반응 단계
Step A—A solution of 4-methyl-N-phenyl-3-oxopentanamide, 12, (5 mmol), 4-benzyloxybenzaldehyde (5 mmol) and pyridine (1 mL) in xylene (100 mL) is heated at reflux, with azeotropic removal of water. The progress of the reaction is monitored by tlc. When the reaction is complete, the solvent is removed under reduced pressure, and the residue is chromatographed to afford 2-(4-benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide, 13, (R=4-benzyloxy).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06355810B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-dd175ec9fb224853972661988935f5aa |
| 출처 메모 | uspto-grants-2002_03 |