Selenium Dioxide → 5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester
반응식
[C:1]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:7][C:8]=1[CH3:9])#[N:2].[Se](=O)=[O:22]>CCOCC>[C:1]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:7][C:8]=1[CH:9]=[O:22])#[N:2]참가 물질
4
실험 절차
27 g of 5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 12.2 g selenium dioxide (0.11 mol) are refluxed together in diethyleneglycoldimethyl ether with stirring for 1.5 hours. The solvent is distilled off in vacuo and the oily residue crystallized with diethyl ether. Yield 19 g (66%); m.p. 62°-64° C. (ether).
후처리
- distillationThe solvent is distilled off in vacuo
- customthe oily residue crystallized with diethyl ether
출처 및 근거
- ORD 기록
- ord-08848c8983c8401ca0f082b68172436a
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04223142
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