Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sec-Butylamine | HCID 24874 | — |
| 반응물 | Ethyl 2-chloro-5-cyano-6-methylnicotinate | HCID 2758816 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester | HCID 86737219 | — |
반응 단계
22.4 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) of Example 1(b) are treated in 100 ml of ethanol with 15 g sec. butylamine at reflux temperature with stirring. After the addition of the amine is completed, the solution is poured into 200 ml of cold water, and the amino compound is filtered off. Yield 22 g (84%); m.p. 55°-57° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04223142 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-8ae000ca848e414ea1ff080f0b71df04 |
| 출처 메모 | uspto-grants-1980_09 |