Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dioxane → 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | ((p-(Benzyloxy)phenoxy)methyl)oxirane | HCID 119882 | — |
| 반응물 | 1-(2-Methoxy-5-methylphenyl)piperazine dihydrochloride | HCID 22625397 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol | HCID 22625405 | 89.5% |
반응 단계
Using 1.37 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane, 50 ml of dioxane, 1.49 g of 1-(2-methoxy-5-methylphenyl)piperazine dihydrochloride and 1.6 ml of triethylamine, reaction and workup were carried out as in Example 1-A. Purification by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1) gave 2.21 g of pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06358515B2 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-69d41a5bc4b94670b9a110e6d04c642f |
| 출처 메모 | uspto-grants-2002_03 |