Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1,2-Dimethylbenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 2-Methylbenzimidazole | HCID 11984 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 1,2-Dimethylbenzimidazole | HCID 312693 | 54.2% |
반응 단계
To 10 grams of 2-methyl benzimidazole (75 mM), crushed 25 grams of crushed KOH (450 mM) in 300 ml acetone, methyl iodide (15 grams, 105 mM) was added at a continuous drip for 0.5 hours, at room temperature. Following additional 0.5 hour, water was added, the reaction extracted with dichloromethane, evaporated and chromatographed on silica gel to yield 6 grams (54%) of 1,2-dimethyl benzimidazole as a white solid having a melting point of 102° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06358954B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-e1a98b1a47df4324be83e13f054dcad2 |
| 출처 메모 | uspto-grants-2002_03 |