Water → Benzeneacetic acid, 4-(1,1-dimethylethyl)-

HRID 277720

반응식

HRID 277720 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].O>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 962WaterHCID 605629Methyl p-tert-butylphenylacetate

생성물 1

HCID 118343Benzeneacetic acid, 4-(1,1-dimethylethyl)-수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 4-t-butylphenylacetate (20 mmol) was dissolved in MeOH (160 mL) and treated with water (40 mL) and LiOH monohydrate (30 mmol). The reaction was allowed to stir at room temperature overnight. Volatiles were removed under reduced pressure, the remaining residue was diluted with water and neutralized to ph 4 with 1 N sulfuric acid. The resulting solids were filtered, washed with water and dried to leave 4-t-butylphenylacetic acid as an off-white solid (3.8 g, 99%).

후처리

  1. customVolatiles were removed under reduced pressure
  2. additionthe remaining residue was diluted with water
  3. filtrationThe resulting solids were filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-af08657aad9e4b77a676d6e70de6dc3d
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358945B1

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