Dichloromethane → (4-bromo-2-methyl-1H-imidazol-5-yl)methanol
반응식
[Br:1][C:2]1[N:3]=[C:4]([CH3:9])[NH:5][C:6]=1[CH2:7][OH:8].C(Cl)Cl>[O-2].[O-2].[Mn+4].O1CCOCC1>[Br:1][C:2]1[N:3]=[C:4]([CH3:9])[NH:5][C:6]=1[CH2:7][OH:8].[Br:1][C:2]1[N:3]=[C:4]([CH3:9])[NH:5][C:6]=1[CH:7]=[O:8]참가 물질
6
실험 절차
4-Bromo-5-hydroxymethyl-2-methylimidazole was prepared according to the procedure described by S. P. Watson, Synthetic Communications, 22, 2971-2977 (1992). A solution of 4-bromo-5-hydroxymethyl-2-methylimidazole (4.18 g, 21.9 mmol) was refluxed with manganese dioxide (16.1 g) in 1:1 methylene chloride:dioxane (200 mL) for 16 h. The cooled reaction was filtered through celite and concentrated to yield the title compound as a pale yellow solid.
후처리
- customThe cooled reaction
- filtrationwas filtered through celite and
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a69c3b93bb5448ffb7e22f443cf70030
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06358956B1
반응 노트
불러오는 중…