Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 4-[(5-Formylimidazol-1-yl)methyl]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole | HCID 10198247 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-[(5-Formylimidazol-1-yl)methyl]benzonitrile | HCID 10632289 | — |
반응 단계
To a solution of the alcohol from Step D (21.5 g, 101 mmol) in 500 mL of DMSO at room temperature was added triethylamine (56 mL, 402 mmol), then SO3-pyridine complex (40.5 g, 254 mmol). After 45 minutes, the reaction was poured into 2.5 L of EtOAc, washed with water (4×1 L) and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the aldehyde as a white powder which was sufficiently pure for use in a subsequent step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06358956B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-4ae5390a0919411da85b74278e8c9bd7 |
| 출처 메모 | uspto-grants-2002_03 |