Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 5-(1-Hydroxy-2-isopropylaminobutyl)-8-isobutyryloxy-3,4-dihydrocarbostyril hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Isobutyryl chloride | HCID 62325 | — |
| 반응물 | 5-(1-Hydroxy-2-isopropylaminobutyl)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride | HCID 23342111 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 5-(1-Hydroxy-2-isopropylaminobutyl)-8-isobutyryloxy-3,4-dihydrocarbostyril hydrochloride | HCID 23342105 | — |
반응 단계
25 ml of pyridine was added to 1 g of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride, and 3 ml of isobutyryl chloride was added dropwise to the mixture while cooling with ice-water and stirring followed by stirring for 3 hours. After addition of about 200 ml of diethyl ether, acetone was added to the precipitate formed to obtain a crystalline product. The product thus obtained was recrystallized from acetone to obtain 0.8 g of 5-(1-hydroxy-2-isopropylaminobutyl)-8-isobutyryloxy-3,4-dihydrocarbostyril hydrochloride having a melting point of 239°-240° C. (with coloration and decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04223137 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-3ba34678f508400ba2fa46962c693bc6 |
| 출처 메모 | uspto-grants-1980_09 |