Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl Peroxide → Bromo(4-fluorophenyl)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Bromo(4-fluorophenyl)acetic acid | HCID 16217752 | — |
반응 단계
The 4-fluorophenylacetic acid (20 g, 0.13 mol), benzoyl peroxide (130 mg, 0.540 mmol), and N-bromosuccinimide (23.1 g, 0.130 mol) were combined in 500 ml carbon tetrachloride under N2 and refluxed under UV irradiation (GE sunlamp) for 5 hours. The reaction was cooled to RT and the succinimide filtered away. The carbon tetrachloride was removed in vacuo and the remaining oil recrystallized from hexanes yielding 26.2 g (87%) of product as a light yellow solid. EA, MS(FD).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06358971B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-df6e30e07dca4e87a46146c58d561673 |
| 출처 메모 | uspto-grants-2002_03 |