2-(3-Cyanopropyl)-1,3-dioxolane → 2-(4-Aminobutyl)-1,3-dioxolane
반응식
[C:1]([CH2:3][CH2:4][CH2:5][CH:6]1[O:10][CH2:9][CH2:8][O:7]1)#[N:2].[H][H]>N.C(O)C.[Ru]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH:6]1[O:10][CH2:9][CH2:8][O:7]1참가 물질
6
실험 절차
To a solution of 14.5 gm (10.3 mmol) 2-(3-Cyanopropyl)-1,3-dioxolane in anhydrous ammonia and ethanol was added 5% ruthenium on aluminum oxide. The reaction mixture was hydrogenated with an initial hydrogen pressure of 100 p.s.i. at ambient temperature for 32 hours. The reaction mixture was filtered and the filtrate concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 12.0 gm (80.5%) of the product. MS (FD+) (m/e): 146.
후처리
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated under reduced pressure
- customThe residue was purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-720a3c0dc19a459f94cd736d115f9ba1
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06358972B1
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