1-Naphthylamine → HCID 12295945, 화합물

HRID 278026노트

반응식

HRID 278026 반응식
[N:1]#[C:2]Br.[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1>C1(C)C=CC=CC=1>[C:5]1([NH:4][C:2]#[N:1])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 86401-NaphthylamineHCID 10476Cyanogen Bromide

생성물 1

HCID 12295945HCID 12295945, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Cyanogen bromide (4.4 gm, 41.9 mmol) was added in portions to the stirred and ice-bath cooled solution of 1-aminonaphthalene (10.0 gm, 69.8 mmol) in toluene (100 mL). After 0.5 hour, the cooling bath was removed the reaction mixture was stirred at room temperature for 12 hours. The precipitate was filtered and the solid was triturated with water (150 mL) for 0.5 hour. The resulted solid was filtered and washed with water (4×20 mL) and the solid was dried in vacuum oven at 40° C. This material (4.6 gm) was used as such without any further purification.

후처리

  1. customthe cooling bath was removed the reaction mixture
  2. stirringwas stirred at room temperature for 12 hours
  3. filtrationThe precipitate was filtered
  4. customthe solid was triturated with water (150 mL) for 0.5 hour
  5. filtrationThe resulted solid was filtered
  6. washwashed with water (4×20 mL)
  7. customthe solid was dried in vacuum oven at 40° C
  8. customsuch without any further purification

출처 및 근거

ORD 기록
ord-d4901e41c2b2428b94ea0144e652eff6
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358993B1

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