Diisopropylethylamine → (2-(Pyrid-4-yl)-1h-benzimidazole-4-carbonyl)-(l)-leucine methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733286	—
반응물	2-Pyridin-4-yl-3H-benzoimidazole-4-carboxylic acid	HCID 11207170	—
용매	Dimethylformamide	HCID 6228	—
생성물	(2-(Pyrid-4-yl)-1h-benzimidazole-4-carbonyl)-(l)-leucine methyl ester	HCID 15480893	—

반응 단계

120 mg (0.5 mmol) of 2-(pyrid-4-yl)-1H-benzimidazole-4-carboxylic acid (1d) and 84 mg (0.5 mmol) of H-(L)-leucine methyl ester were dissolved in 5 ml of DMF. 164 mg (0.5 mmol) of TOTU and 0.086 ml of diisopropylethylamine were added and the mixture was stirred at RT for 3 h. The precipitate was filtered off and the filtrate was concentrated. The residue was dissolved in ethyl acetate, the solution was washed with water, and the organic phase was dried using anhydrous sodium sulfate and concentrated. Yield: 180 mg (98%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06358978B1
출처 데이터셋	uspto-grants-2002_03
ORD ID	ord-184fe2b0b5f24a8d8c53a2db5518b886
출처 메모	uspto-grants-2002_03