Dimethylformamide → (2-(Pyrid-4-yl)-1H-benzimidazole-4-carbonyl)-(L)-valinamide

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733286	—
반응물	2-Pyridin-4-yl-3H-benzoimidazole-4-carboxylic acid	HCID 11207170	—
생성물	(2-(Pyrid-4-yl)-1H-benzimidazole-4-carbonyl)-(L)-valinamide	HCID 11416447	—

반응 단계

120 mg (0.5 mmol) of 2-(pyrid-4-yl)-1H-benzimidazole-4-carboxylic acid (1d) and 76.4 mg (0.5 mmol) of H-(L)-valinamide were dissolved in 5 ml of DMF. 164 mg (0.5 mmol) of TOTU and 0.086 ml of diisopropylethylamine were added and the mixture was stirred at RT for 3 h. The precipitate was filtered off and the filtrate was concentrated. The residue was dissolved in ethyl acetate, the solution was washed with saturated sodium chloride solution, and the organic phase was dried using anhydride sodium sulfate and concentrated. Yield: 168 mg (99%). (M+H)+=338.2 (Cl+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06358978B1
출처 데이터셋	uspto-grants-2002_03
ORD ID	ord-cc209c226de84ecb942c3b52c5f48169
출처 메모	uspto-grants-2002_03