Potassium Hydroxide → HCID 22627677, 화합물
반응식
[CH:1]([S:4][C:5]([CH3:12])([CH3:11])[C:6]([O:8]CC)=[O:7])([CH3:3])[CH3:2].[OH-].[K+]>C(O)C.O>[CH:1]([S:4][C:5]([CH3:12])([CH3:11])[C:6]([OH:8])=[O:7])([CH3:3])[CH3:2]참가 물질
5
실험 절차
A mixture of ethyl 2-(isopropylthio)-2-methylpropionate (5.4 g, 30 mmol) and potassium hydroxide (5.0 g, 90 mmol) in ethanol is refluxed for 6 hours, cooled, and concentrated in vacuo to obtain a residue. The residue is diluted with water, washed with ether, acidified with hydrochloric acid, and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. The solid is washed with chloroform and dried under reduced pressure to give the title product as a solid, mp 51.5-52.5° C.
후처리
- temperatureis refluxed for 6 hours
- temperaturecooled
- concentrationconcentrated in vacuo
- customto obtain a residue
- washwashed with ether
- extractionextracted with ether
- washThe combined organic extracts are washed sequentially with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated in vacuo
- customto obtain a solid
- washThe solid is washed with chloroform
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-0e9ebb424c524824b57dba70cf1006b6
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06359009B1
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