Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aluminum(III) Chloride → Ibuprofen, (+-)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 2-(p-Isobutylphenyl)propionic acid benzyl ester | HCID 10424662 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Nitromethane | HCID 6375 | — |
| 용매 | Anisole | HCID 7519 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ibuprofen, (+-)- | HCID 3672 | 91% |
반응 단계
To a solution of benzyl 2-p-isobutylphenylpropionate (3 g) in methylene chloride (18 ml) are added a solution of aluminum chloride (4 g) in nitromethane (50 ml) and anisole (3 ml) at 0° C., and the mixture is stirred at room temperature for 6 hours. The reaction mixture is diluted with ethyl acetate, washed with hydrochloric acid and water, dried and evaporated. The residue is recrystallized with n-hexane to give 2-p-isobutylphenylpropionic acid (186 mg) melting at 75°-77.5° C. Yield 91%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04223132 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-fe55e9d7d722407189fc1a59ff07f4bc |
| 출처 메모 | uspto-grants-1980_09 |