Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromoaniline → 6-Bromoquinolin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 생성물 | 6-Bromoquinolin-2(1H)-one | HCID 12378943 | — |
| 생성물 | 6-Bromo-2-chloroquinoline | HCID 12894086 | — |
반응 단계
The title compound is prepared from 4-bromoaniline and cinnamoyl chloride according to the procedure described in J. Chem. Soc., Perkin Trans. I, 1972, 1648. The crude 6-bromo-1H-quinolin-2-one intermediate obtained is triturated in Et2O/hexanes and filtered to give a beige solid which is used directly in the chlorination step. The crude product is recrystallized in MeOH to afford the title compound as a beige solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731315 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-d45dd22efe384d6e8d41b31969ccab08 |
| 출처 메모 | uspto-grants-1998_03 |