Hydroxycaprylic Acid → Methyl 2-hydroxyoctanoate

HRID 278462

반응식

HRID 278462 반응식
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([OH:5])=[O:4].[CH3:12]O.Cl>>[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH3:12])=[O:4]

참가 물질

3

반응물 2

HCID 94180Hydroxycaprylic AcidHCID 21893726Hydrochloride methanol

생성물 1

HCID 10487462Methyl 2-hydroxyoctanoate

실험 절차

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

후처리

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customThe residue was partitioned between ethyl acetate and water
  3. washThe organic layer was washed with aqueous NaHCO3 solution
  4. dry with materialdried over sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-40c1c3396bad46d08b4711877faefc2a
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359145B1

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