Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glyoxylic Acid → (+-)-4-Hydroxymandelic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glyoxylic Acid | HCID 760 | — |
| 반응물 | Phenol | HCID 996 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (+-)-4-Hydroxymandelic acid | HCID 328 | — |
반응 단계
The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06359172B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-89b113ed39194d25bd2436f24bca2c8a |
| 출처 메모 | uspto-grants-2002_03 |