Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 반응물 | 1-Tritylpiperidine-4-carboxylic acid | HCID 20520182 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine | HCID 22628088 | — |
반응 단계
To a mixture of 1-tritylpiperidine-4-carboxylic acid (7.0 g), O,N-dimethylhydroxylamine hydrochloride (2.0 g) and triethylamine (2.9 ml) in dichloromethane (70 ml) was added WSC (3.97 g), and the mixture was stirred at room temperature for 1 hour and concentrated. To the residue was added ethyl acetate, and the mixture was washed with water, dried (MgSO4) and concentrated. The resulting crystals (6.3 g) were washed with isopropylether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06359134B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-13e3f414752049a18edaff60a4782d74 |
| 출처 메모 | uspto-grants-2002_03 |