Water → 4-Bromo-N,N-diisopropylbenzylamine

HRID 278572

반응식

HRID 278572 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([NH:13][CH:14]([CH3:16])[CH3:15])([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:13]([CH:14]([CH3:16])[CH3:15])[CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7912DiisopropylamineHCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromide

생성물 1

HCID 5987704-Bromo-N,N-diisopropylbenzylamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-bromobenzylbromide (5.0 g), N,N-diisopropylamine (7.85 ml) and potassium carbonate (2.76 g) in dimethylformamide (50 ml) was stirred at 80° C. for 2 hours. To the mixture was added water, and the mixture was extracted with ether. The extract was washed with water, dried (MgSO4) and concentrated to give the title compound (5.0 g).

후처리

  1. extractionthe mixture was extracted with ether
  2. washThe extract was washed with water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0947629a38f245a280dfe00ef647a3cd
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359134B1

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