Potassium Carbonate → 1-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole

HRID 2787노트

반응식

HRID 2787 반응식
[C:1]1([C:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH:20]=[CH:19]3)[CH2:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 825531,2,3,6-Tetrahydro-4-phenylpyridineHCID 123407571-(4-Chlorobutyl)-1H-indole

생성물 1

HCID 219978811-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A mixture of 4.8 g (30 mmol) of 4-phenyl-1,2,3,6-tetrahydropyridine, 6.22 g of 1-(4-chlorobutyl)indole and 8.3 g of potassium carbonate in 100 ml of dimethylformamide is heated at 90° C. for 3 hours. Evaporation to dryness is then carried out at reduced pressure, the residue is redissolved in chloroform and washing is carried out repeatedly with water. The organic phase is dried with anhydrous sodium sulfate and evaporation is carried out at reduced pressure, a crude product being obtained which is purified by chromatography on silica gel. 5.7 g (17.3 mmol). of 1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole are obtained.

후처리

  1. customEvaporation to dryness
  2. dissolutionthe residue is redissolved in chloroform
  3. washwashing
  4. dry with materialThe organic phase is dried with anhydrous sodium sulfate and evaporation
  5. customa crude product being obtained which
  6. customis purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-a1beaa3b1b63410ca82b9562ddec3ef2
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731331

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