Potassium Carbonate → 1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

HRID 278703노트

반응식

HRID 278703 반응식
[CH3:1][O:2][C:3]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][CH:7]=2)[CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([C:3]2([O:2][CH3:1])[CH2:4][CH2:5]2)=[CH:7][CH:8]=1)#[CH:13]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 22568890[4-(1-Methoxycyclopropyl)phenylethynyl]-trimethylsilane2회

생성물 1

HCID 225689501-Ethynyl-4-(1-methoxycyclopropyl)-benzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Using General Procedure E; [4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

출처 및 근거

ORD 기록
ord-fe225fe030e344ff90d7a51a7a404ca5
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359135B1

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