Water → β-Amino-3,4-difluorobenzeneethanol

HRID 278902노트

반응식

HRID 278902 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][O:12]C(=O)[NH:10]2)[CH:5]=[CH:6][C:7]=1[F:8].O.[OH-].[K+]>C(O)C>[NH2:10][CH:9]([C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=1)[CH2:13][OH:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 220487464-(3,4-Difluorophenyl)-1,3-oxazolidin-2-one

생성물 1

HCID 22048878β-Amino-3,4-difluorobenzeneethanol수율 87.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of (+)-4-(3,4-difluorophenyl)-oxazolidin-2-one (1.39 mmol, 0.27 g) in 5.0 mL ethanol was added 5.0 mL of water and pellets of potassium hydroxide (5.0 mmol, 0.28 g). The resulting solution was then heated to reflux overnight. The solvent was removed in vacuo and the resulting residue was extracted with EtOAc (2×50 mL). The organic extracts were washed with brine and the organic layer was dried over Na2SO4. It was filtered and the solvent was removed in vacuo to obtain (+)-2-amino-2-(3,4-difluorophenyl)-ethanol as a white solid (0.21 g, 87% yield).

후처리

  1. temperatureThe resulting solution was then heated
  2. temperatureto reflux overnight
  3. customThe solvent was removed in vacuo
  4. extractionthe resulting residue was extracted with EtOAc (2×50 mL)
  5. washThe organic extracts were washed with brine
  6. dry with materialthe organic layer was dried over Na2SO4
  7. filtrationIt was filtered
  8. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-2e571f8b58f8487aaa9eeb32e8ab214e
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362182B1

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