Acetylacetone → 3-Carbamoyl-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine

HRID 27900노트

반응식

HRID 27900 반응식
[C:1]([C:4]1[N:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1)(=[O:3])[NH2:2].[C:12]([CH2:15][C:16](=O)[CH3:17])(=O)[CH3:13]>C(O)C>[C:1]([C:4]1[N:5]=[N:6][C:7]([N:10]2[C:16]([CH3:17])=[CH:15][C:12]([CH3:13])=[N:11]2)=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

참가 물질

4

반응물 2

HCID 31261AcetylacetoneHCID 71653Hydracarbazine

생성물 1

HCID 125628413-Carbamoyl-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.53 g (0.01 moles) of 3-carbamoyl-6-pyridazinyl-hydrazine, 1.1 g (0.011 moles) of acetylacetone and 15 ml ethanol is heated to reflux under stirring for 3 hours. After cooling the separated crystals are filtered, washed with ethanol and dried. Yield: 2.05 g (95%); m.p.: 256°-257° C.

후처리

  1. temperatureis heated
  2. temperatureto reflux
  3. temperatureAfter cooling the separated crystals
  4. filtrationare filtered
  5. washwashed with ethanol
  6. customdried

출처 및 근거

ORD 기록
ord-e11618e8430e4752b2c31929afaf3602
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224325

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