2-Benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione → 2-Hydroxy-5-methyl-benzo[de]isoquinoline-1,3-dione

HRID 279000노트

반응식

HRID 279000 반응식
C([O:8][N:9]1[C:18](=[O:19])[C:17]2[CH:20]=[C:21]([CH3:23])[CH:22]=[C:15]3[C:16]=2[C:11](=[CH:12][CH:13]=[CH:14]3)[C:10]1=[O:24])C1C=CC=CC=1>CC(N(C)C)=O.[Pd]>[OH:8][N:9]1[C:18](=[O:19])[C:17]2[CH:20]=[C:21]([CH3:23])[CH:22]=[C:15]3[C:16]=2[C:11](=[CH:12][CH:13]=[CH:14]3)[C:10]1=[O:24]

참가 물질

4

반응물 1

HCID 226240502-Benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione

생성물 1

HCID 226239402-Hydroxy-5-methyl-benzo[de]isoquinoline-1,3-dione수율 33.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 31374Dimethylacetamide용매

실험 절차

The hydrogenation of 2-benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione (0.4 g, 1.3 mmol, from Example P) was performed in the presence of 10% Pd/C (0.1 g) in DMA (20 mL). Purification of crude product by column chromatography (silica gel using 10% methanol in dichloromethane) gave 0.1 g of the title compound, mp 251-253° C.;

후처리

  1. customPurification of crude product by column chromatography (silica gel using 10% methanol in dichloromethane)

출처 및 근거

ORD 기록
ord-33a6d9159eb1442482fa8c04391dedde
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362181B1

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