p-Fluoronitrobenzene → 2-(4-Nitrophenyl)-2h-1,2,3-triazole

HRID 279163노트

반응식

HRID 279163 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[N:12]1>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:12]2[N:13]=[CH:14][CH:15]=[N:11]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 9590p-FluoronitrobenzeneHCID 178418936HCID 178418936, 화합물

생성물 1

HCID 2781582-(4-Nitrophenyl)-2h-1,2,3-triazole수율 66.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-Fluoronitrobenzene (21 g) was reacted with 1H-1,2,3-triazole (12.4 g) in the same manner as in Reference Example 9. The resultant was cooled and poured into water. The precipitated crystals were collected by filtration and purified by silica gel chromatography (eluent: dichloromethane to dichloromethane/acetone=8/1). The first eluted fraction was recrystallized from dichloromethane-diisopropyl ether to give 2-(4-nitrophenyl)-2H-1,2,3-triazole (18.8 g) as pale yellow prisms.

후처리

  1. temperatureThe resultant was cooled
  2. filtrationThe precipitated crystals were collected by filtration
  3. custompurified by silica gel chromatography (eluent: dichloromethane to dichloromethane/acetone=8/1)
  4. customThe first eluted fraction was recrystallized from dichloromethane-diisopropyl ether

출처 및 근거

ORD 기록
ord-fbd7cc109d7e47a9a9616d1326ba7ffc
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362206B1

반응 노트

불러오는 중…