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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 279183생성일: 2026년 10월 26일

1-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole, (2R-cis)- → 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(1H-1-pyrazolyl)phenyl]-3(2H,4H)-1,2,4-triazolone

https://huagongshe.com/reaction/279183

반응식

참여 물질

역할이름HCID투입량
반응물1-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole, (2R-cis)-HCID 10131191—
반응물4-[4-(1H-1-pyrazolyl)phenyl]-3(2H,4H)-1,2,4-triazoloneHCID 10775671—
생성물2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(1H-1-pyrazolyl)phenyl]-3(2H,4H)-1,2,4-triazoloneHCID 3002951—

반응 단계

(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl)methyloxirane was reacted with 4-[4-(1H-1-pyrazolyl)phenyl]-3(2H,4H)-1,2,4-triazolone in the same manner as in Working Example 11 to give 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(1H-1-pyrazolyl )phenyl]-3(2H,4H)-1,2,4-triazolone (Compound 19).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06362206B1
출처 데이터셋uspto-grants-2002_03
ORD IDord-08bcc828b88147f6a6f24b88690751aa
출처 메모uspto-grants-2002_03