Ethanol hydrochloride → 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride

HRID 2792

반응식

HRID 2792 반응식
Cl.C(O)C.[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH:20]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)[C:10]=1[Cl:11]>C(O)C>[ClH:5].[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:21]2)[C:10]=1[Cl:11]

참가 물질

4

반응물 2

HCID 21887872Ethanol hydrochlorideHCID 219978754,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole

생성물 1

HCID 219978744,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride수율 189.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.5 ml of an 8.4N hydrochloric acid/ethanol solution are added to a solution, cooled in an ice bath, of 7.4 g (20.3 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole in 15 ml of absolute ethanol. After a few minutes, a precipitate appears which is filtered, washed with cold ethanol and dried, 7.7 g (19.2 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride being obtained.

후처리

  1. waitAfter a few minutes
  2. filtrationis filtered
  3. washwashed with cold ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-4897d8268b054a86a723074d1e00d03f
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731331

연결된 노트

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