Ethanol hydrochloride → 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride
반응식
Cl.C(O)C.[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH:20]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)[C:10]=1[Cl:11]>C(O)C>[ClH:5].[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:21]2)[C:10]=1[Cl:11]참가 물질
4
실험 절차
2.5 ml of an 8.4N hydrochloric acid/ethanol solution are added to a solution, cooled in an ice bath, of 7.4 g (20.3 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole in 15 ml of absolute ethanol. After a few minutes, a precipitate appears which is filtered, washed with cold ethanol and dried, 7.7 g (19.2 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride being obtained.