Triethylamine → 5-phenyl-penta-2,4-dienoic acid-N-(2-carboxy-4-fluoro-phenyl)-amide

HRID 279204

반응식

HRID 279204 반응식
[C:1]1([CH:7]=[CH:8][CH:9]=[CH:10][C:11](Cl)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:16]=1[C:17]([OH:19])=[O:18].C(N(CC)CC)C>O1CCCC1>[C:17]([C:16]1[CH:20]=[C:21]([F:24])[CH:22]=[CH:23][C:15]=1[NH:14][C:11](=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:19])=[O:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1014122-Amino-5-fluorobenzoic acidHCID 30848092,4-Pentadienoyl chloride, 5-phenyl-

생성물 1

HCID 739936225-phenyl-penta-2,4-dienoic acid-N-(2-carboxy-4-fluoro-phenyl)-amide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to Example 31 from 5-phenyl-penta-2,4-dienoic acid chloride and 2-amino-5-fluoro-benzoic acid in tetrahydrofuran with the addition of triethylamine.

출처 및 근거

ORD 기록
ord-3b01083c5a344918b84c9a2c5bceb051
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362210B1

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