7-Deoxytaxol → HCID 10929863, 화합물

HRID 279231노트

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HRID 279231 반응식
[CH3:1][C:2]1[C@@H:19]([O:20]C([C@H](O)[C@@H](NC(C2C=CC=CC=2)=O)C2C=CC=CC=2)=O)[CH2:18][C@:14]2([OH:41])[C:15]([CH3:17])([CH3:16])[C:3]=1[C@@H:4]([O:58][C:59]([CH3:61])=[O:60])[C:5]([C@@:7]1([CH3:57])[C@H:12]([C@@H:13]2[O:42][C:43]([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)=[O:44])[C@:11]2([O:53][C:54]([CH3:56])=[O:55])[CH2:51][O:52][C@@H:10]2[CH2:9][CH2:8]1)=[O:6]>C(Cl)Cl.CO>[CH3:1][C:2]1[C@@H:19]([OH:20])[CH2:18][C@:14]2([OH:41])[C:15]([CH3:16])([CH3:17])[C:3]=1[C@@H:4]([O:58][C:59]([CH3:61])=[O:60])[C:5]([C@@:7]1([CH3:57])[C@H:12]([C@@H:13]2[O:42][C:43]([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)=[O:44])[C@:11]2([O:53][C:54]([CH3:56])=[O:55])[CH2:51][O:52][C@@H:10]2[CH2:9][CH2:8]1)=[O:6]

참가 물질

4

반응물 1

HCID 99189837-Deoxytaxol

생성물 1

HCID 10929863HCID 10929863, 화합물수율 79.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

(2) To a solution of 7-deoxy paclitaxel (461 mg, 0.55 mmol) in 20 mL of methylene chloride and 0.4 mL of methanol was added Bu4NBH4 (283 mg, 1.1 mmol) and the solution stirred for 24 hours. The solution was quenched with saturated NH4Cl and extracted with ethyl acetate. The solution was dried over MgSO4 and concentrated. The residue was chromatographed over silica gel using hexane-ethyl acetate (1:1) to give 249 mg of product (79%).

후처리

  1. customThe solution was quenched with saturated NH4Cl
  2. extractionextracted with ethyl acetate
  3. dry with materialThe solution was dried over MgSO4
  4. concentrationconcentrated
  5. customThe residue was chromatographed over silica gel

출처 및 근거

ORD 기록
ord-f4318bb2d32346678dd0684effc55fdf
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362217B1

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