Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonate → alpha-Cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonate | HCID 85257 | — |
| 반응물 | Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- | HCID 93218 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 반응물 | 2-(1-Benzothiophen-2-yl)-3-methylbutanoic acid | HCID 23340392 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 생성물 | alpha-Cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate | HCID 23340427 | — |
반응 단계
A mixture of 2-(2-benzothienyl)-3-methylbutanoic acid (0.5 g, 21.4 mmol) and KHCO3 (21.4 mmol) in 10 ml THF/DMF (1:1) is stirred for 10 minutes. Then the mesylate of α-cyano-3-phenoxybenzyl alcohol (0.65 g, 21.4 mmol) in 3 ml THF is added followed by stirring overnight. The mixture is diluted with 100 ml ether, washed with water and saturated NaCl, dried and solvent stripped to yield crude product. The product is isolated using thin layer chromatography developing with 15% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate, viscous liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04224330 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-3e7d6f062fd54e5f8e5ba42178928462 |
| 출처 메모 | uspto-grants-1980_09 |