Methanesulfonate → alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate

HRID 27927

반응식

HRID 27927 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12])=[CH:2]1.S([O-])(=O)(=O)C.[C:22]([CH:24](O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:26]=1)#[N:23].C(OCC)(=O)C.CCCCCC>C1COCC1.CN(C=O)C>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([O:13][CH:24]([C:22]#[N:23])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH:26]=2)=[O:12])=[CH:2]1

참가 물질

6

반응물 4

HCID 85257MethanesulfonateHCID 93218Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)-HCID 21226206Ethyl acetate hexaneHCID 537164122-(1-Benzothiophen-3-yl)-3-methylbutanoic acid

생성물 1

HCID 54429257alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate

시약·촉매·용매 1

HCID 21974620tetrahydrofuran N,N-dimethylformamide용매2회

실험 절차

A mixture of 2-(3-benzothienyl)-3-methylbutanoic acid (3.4 mmol) and KCHO3 (3.4 mmol) on 15 ml THF/DMF (1:1) is stirred for about 15 minutes. The mesylate of α-cyano-3-phenoxybenzyl alcohol (3.4 mmol) in 5 ml THF/DMF is added and the reaction mixture stirred for about 48 hours. The reaction is worked up as in Example 2, developing with 10% ethyl acetate/hexane to yield α-cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate, colorless thick liquid.

후처리

  1. stirringthe reaction mixture stirred for about 48 hours

출처 및 근거

ORD 기록
ord-62de4d5dcc5440a6a1556c6338ced5c4
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224330

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