Ether hydrochloride → HCID 18426178, 화합물

HRID 279286노트

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HRID 279286 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH2:10][CH:9]([NH:13]C(OC(C)(C)C)=O)[CH2:8]2)=[CH:4][CH:3]=1.[ClH:23].CCOCC>CO>[ClH:1].[ClH:23].[NH2:13][CH:9]1[CH2:10][CH2:11][CH2:12][N:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:22][CH:21]=2)[CH2:8]1

참가 물질

4

반응물 2

HCID 10953452Ether hydrochlorideHCID 18426153HCID 18426153, 화합물

생성물 1

HCID 18426178HCID 18426178, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

A solution of 1-(4-chlorobenzyl)-3-{(tert-butoxycarbonyl)amino}piperidine (2.55 g, 7.85 mmol) in CH3OH (25 mL) was treated with 1 N HCl-Et2O (50 mL). The reaction mixture was stirred at 25° C. for 15 h. The solvent was removed under reduced pressure to afford 3-amino-1-(4-chlorobenzyl)piperidine dihydrochloride as an amorphous solid (2.49 g, quant). The purity was determined by RPLC/MS (>95%),; ESI/MS m/e 225.2 (M++H, C12H18ClN2).

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-1d2a689d53104431af6efce70f81260e
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362177B1

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