Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| 반응물 | 2-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid | HCID 54204673 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate | HCID 54477689 | — |
반응 단계
A mixture of 20 ml DMF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.51 g) and 3-phenoxybenzyl bromide (0.44 g) is stirred, under nitrogen, for about 15 hours. The mixture is then taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ether/hexane to give 3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04224330 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-afd7ba97cc11477984f0728908ef7c09 |
| 출처 메모 | uspto-grants-1980_09 |