Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 69216966, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Boc-D-phenylalanine | HCID 637610 | — |
| 반응물 | {[1-(4-Chlorobenzyl)piperidin-4-yl]methyl}amine | HCID 18426145 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 69216966 | HCID 69216966 | — |
반응 단계
A solution of 1-(4-chlorobenzyl)-4-(aminomethyl)piperidine (100 mg) in CHCl3 (3 mL) was treated with Et3N (0.090 mL), N-(tert-butoxycarbonyl)-D-phenylalanine (122 mg), EDCI (89 mg) and HOBt (62 mg). The reaction mixture was stirred at room temperature for 17 h. The reaction mixture was washed with 1 N aqueous NaOH solution (2 mL×2) and brine (2 mL). The organic layer was dried and concentrated to afford 1-(4-chlorobenzyl)-4-[{N-(tert-butoxycarbonyl)-D-phenylalanyl}aminomethyl]piperidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362177B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-271d712915234380ac470461f9fbd88a |
| 출처 메모 | uspto-grants-2002_03 |