Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-[2-[4-[4-formylphenyl]-3-cyclohexen-1-yl]-propyl] 2-propanesulfonamide → N-[2-[4-(4-cyclopentyl)-3-cyclohexen-1-yl]propyl] 2-propanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-[2-[4-[4-formylphenyl]-3-cyclohexen-1-yl]-propyl] 2-propanesulfonamide | HCID 9841299 | — |
| 반응물 | HCID 178419769 | HCID 178419769 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[2-[4-(4-cyclopentyl)-3-cyclohexen-1-yl]propyl] 2-propanesulfonamide | HCID 15541827 | 45% |
반응 단계
Prepared as in Example 14, using 100 mg (0.25 mmol) of the material prepared in step A of Example 13, 1.25 ml of a 0.5 M solution of bromo cyclopentylzinc (0.63 mmol) and 9 mg (0.012 mmol) of bis(triphenylphosphine)palladium chloride in 1 ml of THF. Afforded 35 mg (45%) of the title compound. Ion Electrospray Mass Spectrum: M+1=314.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362230B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-15430aa9e4524157b5005a08db65127e |
| 출처 메모 | uspto-grants-2002_03 |