7-Benzyloxy-6-methoxy-4-phenoxyquinazoline → 7-Hydroxy-6-methoxy-4-phenoxyquinazoline

HRID 279516노트

반응식

HRID 279516 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27]

참가 물질

3

반응물 1

HCID 218748147-Benzyloxy-6-methoxy-4-phenoxyquinazoline

생성물 1

HCID 1354961377-Hydroxy-6-methoxy-4-phenoxyquinazoline수율 89%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (160 mg, 0.44 mmol) in TFA (3 ml) was heated at reflux for 30 minutes. The solvent was removed by evaporation and the residue treated with aqueous sodium hydrogen carbonate solution. The precipitated product was collected by filtration, washed with water and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (105 mg, 88%).

후처리

  1. temperatureat reflux for 30 minutes
  2. customThe solvent was removed by evaporation
  3. additionthe residue treated with aqueous sodium hydrogen carbonate solution
  4. filtrationThe precipitated product was collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-c507767c98c74063ab746d75277fb41b
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362336B1

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